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InChi: InChI=1S/C21H20N2O2S/c1-11-9-16(24)17(14-5-3-13(4-6-14)12(2)10-22)18-15-7-8-26-20(15)21(25)23-19(11)18/h3-9
InChi: InChI=1S/C5H8O3/c1-2-3-4(6)5(7)8/h2-3H2
5-tetrahydro-1H-1-benzazepin-3-yl acetate
CAS Number: 552325-73-2
CC1(C)C(=CC=CC=CC2=[N+](CCOCCOCCOCCOCCC(=O)ON3C(=O)CCC3=O)C3=CC=CC=C3C2(C)C)N(CCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O)C2=CC=CC=C12
GNE-616 emsirolimus InChi: InChI=1S/C21H20N2O2S/c1-11-9-16(24)17(14-5-3-13(4-6-14)12(2)10-22)18-15-7-8-26-20(15)21(25)23-19(11)18/h3-9GNE 616 is a highly potent, metabolically stable, orally bioavailable, and subtype selective Nav1. 7 inhibitor (Ki of 0. 79 nM and Kd of 0. 38 nM for hNav1. 7) for the treatment of chronic pain. GNE 616 shows >1000 nM Kd and >2500 fold selectivity over hNav1. 1, hNav1. 3, hNav1. 4, and hNav1. 5. Selectivity over hNav1. 2 and hNav1. 6 is more modest at 31 and 73 fold, respectively. Product information CAS Number: 2349371 81 7 Molecular Weight: 537. 53
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